Article
Emergence and transmission pathways of rapidly evolving evolutionary branch C4a strains of human enterovirus 71 in the Central Plain of China.
PloS one - 1 Jan 2011
Zhang Yong, Wang Jitao, Guo Wanshen, Wang Haiyan, Zhu Shuangli, Wang Dongyan, Bai Ruyin, Li Xingle, Yan Dongmei, Wang Huiling, Zhang Yan, Zhu Zhen, Tan Xiaojuan, An Hongqiu, Xu Aiqiang, Xu Wenbo
Abstract excerpt
BACKGROUND: Large-scale outbreaks of hand, foot, and mouth disease (HFMD) occurred repeatedly in the Central Plain of China (Shandong, Anhui, and Henan provinces) from 2007 until now. These epidemics have increased in size and severity each year and are a major public health concern in mainland China. PRINCIPAL FINDINGS: Phylogenetic analysis was performed and a Bayesian Markov chain Monte Carlo tree was...
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