Role of hepatic HCV-RNA level on the severity of chronic hepatitis C and response to antiviral therapy.

doi:10.1016/j.jcv.2011.09.029

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Article

Role of hepatic HCV-RNA level on the severity of chronic hepatitis C and response to antiviral therapy.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jan 2012

Maylin Sarah, Laouénan Cédric, Martinot-Peignoux Michelle, Panhard Xavière, Lapalus Martine, Nicolas-Chanoine Marie Hélène, Bedossa Pierre, Asselah Tarik, Marcellin Patrick

Abstract excerpt

BACKGROUND: Correlation between hepatic HCV-RNA and serum HCV-RNA, severity of liver disease and response to therapy is poorly known. OBJECTIVES: To assess the influence of hepatic HCV-RNA level on severity of liver disease and response to therapy in a large cohort of chronic hepatitis C (CHC) patients. STUDY DESIGN: HCV-RNA was measured in frozen liver biopsies and serum samples from 130 CHC patients the day of...

Topics

Adult
Biopsy
Female
Genotype
Hepacivirus
Hepatitis C, Chronic
Humans
Interferon-alpha
Liver
Liver Cirrhosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Multivariate Analysis

RNA, Viral

Retrospective Studies

Ribavirin

Severity of Illness Index

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 22099210
DOI: 10.1016/j.jcv.2011.09.029

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