The Major Aminoglycoside-Modifying Enzyme AAC(3)-II Found in <i>Escherichia coli</i> Determines a Significant Disparity in Its Resistance to Gentamicin and Amikacin in China

Abstract excerpt

The aim of this study was to investigate the prevalence of aminoglycoside-modifying enzymes in Escherichia coli in different areas of China and to explore the relationship between pandemic enzyme type and bacterial resistance to antimicrobial agents in China. Gentamicin- or etimicin-resistant clinical isolates of E. coli were collected from different areas of China, and the in vitro antibacterial activity of 11...

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