A genetic variant in the promoter region of Toll-like receptor 9 and cervical cancer susceptibility.

doi:10.1089/dna.2011.1427

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Article

A genetic variant in the promoter region of Toll-like receptor 9 and cervical cancer susceptibility.

DNA and cell biology - 1 May 2012

Chen Xiaojun, Wang Sumin, Liu Li, Chen Zengyan, Qiang Fulin, Kan Yanjing, Shen Yan, Wu Jiangping, Shen Hongbing, Hu Zhibin

Abstract excerpt

The Toll-like receptors (TLRs) are important for the innate immune system by recognizing pathogen-associated molecular patterns expressed in infectious agents. E6 and E7 protein from HPV16 suppress the host immune response by regulating the TLR9 transcript. Therefore, we hypothesized that a single nucleotide polymorphism in TLR9 may contribute to cervical cancer. We genotyped TLR9 -1486T/C (rs187084) in a...

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PMID: 22059466
DOI: 10.1089/dna.2011.1427

Genes

TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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