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Article

Fragile X CGG repeat variation in Tamil Nadu, South India: a comparison of radioactive and methylation-specific polymerase chain reaction in CGG repeat sizing.

Genetic testing and molecular biomarkers - 1 Feb 2012

Indhumathi Nagarathinam, Singh Deepika, Chong Samuel S, Thelma B K, Arabandi Ramesh, Srisailpathy C R Srikumari

Abstract excerpt

Fragile X syndrome is the most frequent hereditary cause of mental retardation after Down syndrome. Expansion of CGG repeats in the 5' UTR of the fragile X mental retardation gene 1 (FMR1) causes gene inactivation in most of the cases. The FMR1 gene is classified into normal 5-44; gray zone 45-54; premutation 55 to <200; and full mutation ≥ 00 repeats. Precise sizing of FMR1 alleles is important to understand...

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Source

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Identifiers

PMID: 22023245
DOI: 10.1089/gtmb.2011.0102
PMCID: PMC3277926

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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