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Decreased Mitochondrial Function and Increased Brain Inflammation in Bipolar Disorder and Other Neuropsychiatric Diseases

21 Oct 2011

Abstract excerpt

A recent review article by Konradi and coworkers 1 summarized the results of gene expression studies based on analysis of the entire mRNA pool (transcriptome) of brains from patients with bipolar disorder. The transcriptome differs from the genome because it can be shaped by environ-mental influences. The authors concluded that clusters of genes (a) for energy production were down-regulated, (b) for immune...

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PMID: 22020358
DOI: 10.1097/jcp.0b013e318239c190

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