Article
Weak association of anti-sperm antibodies and strong association of familial cryptorchidism/infertility with HLA-DRB1 polymorphisms in prepubertal Ukrainian boys.
Reproductive biology and endocrinology : RB&E - 28 Sept 2011
Kurpisz Maciej, Nakonechnyy Andriy, Niepieklo-Miniewska Wanda, Havrylyuk Anna, Kamieniczna Marzena, Nowakowska Beata, Chopyak Valentyna, Kusnierczyk Piotr
Abstract excerpt
BACKGROUND: Cryptorchidism is a frequent syndrome occurring in 1-2% of males within the first year of age. Autoimmune reactions, particularly directed to testicular elements and/or spermatozoa have been found to be often associated with cryptorchidism. Therefore we investigated in this study the frequency of HLA class II alleles in order to recognize possible genetic predisposition for antisperm antibodies...
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