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Article

Did the GJB2 35delG mutation originate in Iran?

American journal of medical genetics. Part A - 1 Oct 2011

Norouzi Vahideh, Azizi Hiva, Fattahi Zohreh, Esteghamat Fatemehsadat, Bazazzadegan Niloofar, Nishimura Carla, Nikzat Nooshin, Jalalvand Khadijeh, Kahrizi Kimia, Smith Richard J H, Najmabadi Hossein

Abstract excerpt

Mutations in GJB2 are a major cause of autosomal recessive non-syndromic hearing loss (ARNSHL) in many populations. A single mutation of this gene (35delG) accounts for approximately 70% of GJB2 mutations that are associated with ARNSHL in Caucasians in many European countries and also in Iranian. In this study, we used PCR and restriction digestion to genotype five single nucleotide polymorphisms (SNPs) that...

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Identifiers

PMID: 21910243
DOI: 10.1002/ajmg.a.34225
PMCID: PMC4432473

Genes

GJB2

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Did the GJB2 35delG mutation originate in Iran?PMID 21910243Read ↗

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