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Article

A Novel Persistence Associated EBV miRNA Expression Profile Is Disrupted in Neoplasia

25 Aug 2011

Abstract excerpt

We have performed the first extensive profiling of Epstein-Barr virus (EBV) miRNAs on in vivo derived normal and neoplastic infected tissues. We describe a unique pattern of viral miRNA expression by normal infected cells in vivo expressing restricted viral latency programs (germinal center: Latency II and memory B: Latency I/0). This includes the complete absence of 15 of the 34 miRNAs profiled. These consist of...

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PMID: 21901094
DOI: 10.1371/journal.ppat.1002193

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