Article
Characterization of zebrafish dysferlin by morpholino knockdown.
Biochemical and biophysical research communications - 23 Sept 2011
Kawahara Genri, Serafini Peter R, Myers Jennifer A, Alexander Matthew S, Kunkel Louis M
Abstract excerpt
Mutations in the gene encoding dysferlin cause two distinct muscular dystrophy phenotypes: limb-girdle muscular dystrophy type 2B (LGMD-2B) and Miyoshi myopathy (MM). Dysferlin is a large transmembrane protein involved in myoblast fusion and membrane resealing. Zebrafish represent an ideal animal model to use for studying muscle disease including abnormalities of dysferlin. cDNAs of zebrafish dysferlin were...
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