Article
[Polymorphisms of 2B-adrenergic receptor and endothelial NO-Synthase genes in genesis of the hereditary sick sinus node syndrome].
Kardiologiia - 1 Jan 2011
Chernova A A, Nikulina S Iu, Shul'man V A, Kukushkina T S, Voevoda M I, Maksimov V N
Abstract excerpt
In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome (SSNS) ADRA2B and eNOS genes polymorphisms. We have established predominance of homozygote genotype of more rare DD allele in patients with SSNS (28%) compared with subjects of control group (8.99%). We have found predominance of heterozygote genotype 4a/4b in patients with...
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