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Properties and Crystal Structure of Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8

15 Aug 2011

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in homocysteine metabolism. Despite considerable genetic and clinical attention, the reaction mechanism and regulation of this enzyme are not fully understood because of difficult production and poor stability. While recombinant enzymes from thermophilic organisms are often stable and easy to prepare, properties of thermostable...

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PMID: 21858212
DOI: 10.1371/journal.pone.0023716

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