Article
Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.
Journal of proteome research - 7 Oct 2011
Lee Jun-Wei, Liao Pao-Chi, Young Kung-Chia, Chang Christina L, Chen Steve S L, Chang Ting-Tsung, Lai Ming-Derg, Wang Shainn-Wei
Abstract excerpt
The hepatitis C virus core protein (HCVc) forms the viral nucleocapsid and is involved in viral persistence and pathogenesis, possibly by interacting with host factors to modulate viral replication and cellular functions. Here, we identified 36 cellular protein candidates by one-dimensional SDS-PAGE and LC-MS/MS-based proteomics after affinity purification with HCVc174, a matured form of HCVc from HCV-1b...
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