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Blood screening nucleic acid amplification tests for human immunodeficiency virus Type 1 may require two different amplification targets

2 Aug 2011

Abstract excerpt

BACKGROUND: Five cases of human immunodeficiency virus Type 1 (HIV-1) RNA-positive blood donations are described that escaped detection by three different CE-marked nucleic acid amplification technique (NAT) screening assays. These events were associated with two HIV-1 transmissions to recipients of blood components. The implicated NAT assays are monotarget assays and amplify in different viral genome regions...

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PMID: 21810100
DOI: 10.1111/j.1537-2995.2011.03281.x

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