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Article

From genotype to phenotype: two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Cerami Chiara, Marcone Alessandra, Galimberti Daniela, Villa Chiara, Scarpini Elio, Cappa Stefano F

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is a common early-onset dementia, which shows highly heterogeneous phenotypic presentations. Although an autosomal dominant transmission can be found only in about 10% cases, familial aggregation is frequently observed in FTLD. Recently, the progranulin gene (GRN) was reported to be involved in the disease pathogenesis. We describe two clinically different, apparently...

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PMID: 21891869
DOI: 10.3233/JAD-2011-110788

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GRN

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