Article
Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia.
Journal of clinical immunology - 1 Dec 2011
Ye Ying, Carlsson Göran, Wondimu Biniyam, Fahlén Annika, Karlsson-Sjöberg Jenny, Andersson Mats, Engstrand Lars, Yucel-Lindberg Tülay, Modéer Thomas, Pütsep Katrin
Abstract excerpt
BACKGROUND: Patients with severe congenital neutropenia (SCN) often develop periodontitis despite standard medical and dental care. In light of previous findings that mutations in the neutrophil elastase gene, ELANE, are associated with more severe neutropenic phenotypes, we hypothesized an association between the genotype of SCN and development of periodontitis. METHODS: Fourteen Swedish patients with SCN or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.