Article
Copy number variation accuracy in genome-wide association studies.
Human heredity - 1 Jan 2011
Lin Peng, Hartz Sarah M, Wang Jen-Chyong, Krueger Robert F, Foroud Tatiana M, Edenberg Howard J, Nurnberger John I, Brooks Andrew I, Tischfield Jay A, Almasy Laura, Webb Bradley T, Hesselbrock Victor M, Porjesz Bernice, Goate Alison M, Bierut Laura J, Rice John P
Abstract excerpt
BACKGROUND/AIM: Copy number variations (CNVs) are a major source of alterations among individuals and are a potential risk factor in many diseases. Numerous diseases have been linked to deletions and duplications of these chromosomal segments. Data from genome-wide association studies and other microarrays may be used to identify CNVs by several different computer programs, but the reliability of the results has...
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