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Article

Mutants of ubiquinol-cytochrome c2 oxidoreductase resistant to Qo site inhibitors: consequences for ubiquinone and ubiquinol affinity and catalysis.

Biochemistry - 25 Dec 1990

Robertson D E, Daldal F, Dutton P L

Abstract excerpt

Seven single-site mutants in six residues of the cyt b polypeptide of Rhodobacter capsulatus selected for resistance to the Qo site inhibitors stigmatellin, myxothiazol, or mucidin [Daldal, F., Tokito, M.K., Davidson, E., & Faham, M. (1989) EMBO J. 8, 3951-3961] have been characterized by using optical and EPR spectroscopy and single-turnover kinetic analysis. The strains were compared with wild-type strain...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Cytochrome b Group
Electron Spin Resonance Spectroscopy
Electron Transport
Electron Transport Complex III
Fatty Acids, Unsaturated
Kinetics
Methacrylates
Models, Structural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oxidation-Reduction

Polyenes

Protein Conformation

Rhodobacter capsulatus

Strobilurins

Thiazoles

Source

Identifiers

PMID: 2176897
DOI: 10.1021/bi00503a014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2176897-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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