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Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine β-defensin cluster.

Immunogenetics - 1 Oct 2011

Narciandi Fernando, Lloyd Andrew T, Chapwanya Aspinas, O' Farrelly Cliona, Meade Kieran G

Abstract excerpt

β-defensins are small cationic peptides, with potent immunoregulatory and antimicrobial activity which are produced constitutively and inducibly by eukaryotic cells. This study profiles the expression of a cluster of 19 novel defensin genes which spans 320 kb on chromosome 13 in Bos taurus. It also assesses the genetic variation in these genes between two divergently selected cattle breeds. Using quantitative...

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PMID: 21713586
DOI: 10.1007/s00251-011-0551-7

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