Article
Co-segregation of Huntington disease and hereditary spastic paraplegia in 4 generations.
The neurologist - 1 Jul 2011
Panas Marios, Karadima Georgia, Kalfakis Nikolaos, Vassilopoulos Dimitris
Abstract excerpt
INTRODUCTION: Huntington disease (HD) is an autosomal dominant neurodegenerative disease characterized by choreic hyperkinesias, cognitive decline, and psychiatric manifestations, caused by an increased number of CAG repeats in the IT15 gene on chromosome 4p16.3. Silver syndrome is a rare autosomal dominant form of complicated hereditary spastic paraplegia, characterized by lower limb spasticity in addition to...
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