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Article

A probabilistic disease-gene finder for personal genomes.

Genome research - 1 Sept 2011

Yandell Mark, Huff Chad, Hu Hao, Singleton Marc, Moore Barry, Xing Jinchuan, Jorde Lynn B, Reese Martin G

Abstract excerpt

VAAST (the Variant Annotation, Analysis & Search Tool) is a probabilistic search tool for identifying damaged genes and their disease-causing variants in personal genome sequences. VAAST builds on existing amino acid substitution (AAS) and aggregative approaches to variant prioritization, combining elements of both into a single unified likelihood framework that allows users to identify damaged genes and...

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Identifiers

PMID: 21700766
DOI: 10.1101/gr.123158.111
PMCID: PMC3166837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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