Article
Rituximab resistance.
Best practice & research. Clinical haematology - 1 Jun 2011
Rezvani Andrew R, Maloney David G
Abstract excerpt
Rituximab has become a ubiquitous component of treatment regimens for follicular non-Hodgkin lymphoma. Despite widespread clinical use, the mechanisms by which tumor cells resist rituximab-mediated destruction remain unclear. Rituximab relies in part on immune effector mechanisms for its antitumor effect, and thus resistance may be mediated not only by intrinsic tumor-cell alterations but also by the host...
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