Article
Detection of EGFR and K-ras mutations for diagnosis of multiple lung adenocarcinomas.
Frontiers in bioscience (Landmark edition) - 1 Jun 2011
Iwata Teruo, Sugio Kenji, Uramoto Hidetaka, Yamada Sohsuke, Onitsuka Takamitsu, Nose Naohiro, Ono Kenji, Takenoyama Mitsuhiro, Oyama Tsunehiro, Hanagiri Takeshi, Yasumoto Kosei
Abstract excerpt
The incidence of multiple primary lung adenocarcinoma (MPLA) is increasing, and it is important to distinguish MPLA from intrapulmonary metastasis (IPM) in order to determine the therapeutic strategy. However, there is no reliable method to differentiate between the two. The purpose of this study was to distinguish MPLA from IPM based on the gene status of EGFR and K-ras and the morphological Noguchi...
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