Changes in clonal growth, immunophenotype, and morphology during a follow-up study of an acute lymphoblastic leukemia.

doi:10.1007/978-3-642-74643-7_31

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Article

Changes in clonal growth, immunophenotype, and morphology during a follow-up study of an acute lymphoblastic leukemia.

Haematology and blood transfusion - 1 Jan 1990

Reichle A, Volkmann M, Pachmann K, Diddens H, Emmerich B, Rastetter J

Abstract excerpt

Cells of a 21-year-old patient with acute lymphatic leukemia were analyzed for morphology and immunophenotype and for genotype consecutively during the course of disease. Initial therapy with the BMFT-ALL protocol (Bundesministerium für Forschung und Technologie) reduced leukemic cells only marginally. The following high-dose Ara-C, mitoxantrone (HAM) chemotherapy led to a cell reduction of 75% and to a drastic...

Topics

Adult
Antigens, Differentiation, T-Lymphocyte
Antigens, Neoplasm
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Clone Cells
Drug Resistance
Follow-Up Studies
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukemia-Lymphoma, Adult T-Cell

Male

Neoplastic Stem Cells

Phenotype

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 2157643
DOI: 10.1007/978-3-642-74643-7_31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157643-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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