Article
Clinical evaluation of polymerase chain reaction reverse hybridization assay for detection and identification of human papillomavirus type 16 variants.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jul 2011
Sanchez Gloria I, Kleter Bernhard, Gheit Tarik, van Doorn Leen-Jan, de Koning Maurits N C, de Sanjosé Silvia, Alemany Laia, Bosch Xavier F, Tommasino Massimo, Muñoz Nubia, Quint Wim G V
Abstract excerpt
BACKGROUND: Isolates of HPV16 comprise six variants: European (Eu), Asian (As), Asian-American (AA), North American (NA), African-1 (AF1), and African-2 (AF2) with different carcinogenic potentials. Highly reliable automatable techniques for HPV variant genotyping would be helpful to confirm the role of variants in cervical cancer in large epidemiological studies. OBJECTIVE: To validate the performance of a novel...
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