Article
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
European journal of human genetics : EJHG - 1 Oct 2011
Anney Richard J L, Kenny Elaine M, O'Dushlaine Colm, Yaspan Brian L, Parkhomenka Elena, Buxbaum Joseph D, Sutcliffe James, Gill Michael, Gallagher Louise, Buxbaum Joseph D, Sutcliffe James, Gill Michael, Gallagher Louise
Abstract excerpt
Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically robust, replicated major effect genes or SNPs. We apply the principle of the SNP ratio test methodology described by O'Dushlaine et al to over 2100 families from...
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