Article
Nontruncated amino-terminal parathyroid hormone overproduction in two patients with parathyroid carcinoma: a possible link to HRPT2 gene inactivation.
Clinical endocrinology - 1 Jun 2011
Caron Philippe, Simonds William F, Maiza Jean-Christophe, Rubin Mishaela, Cantor Tom, Rousseau Louise, Bilezikian John P, Souberbielle Jean-Claude, D'Amour Pierre
Abstract excerpt
OBJECTIVE: Some patients with parathyroid carcinoma present with an over-production of nontruncated amino-terminal (NT-N) parathyroid hormone (PTH), a post-transcriptionally modified form of PTH(1-84). This is usually picked up on an elevated whole (W) PTH (third-generation)/total (T) (second-generation) PTH assay ratio (N > 0·8). PATIENTS AND DESIGN: Two parathyroid cancer patients with several episodes of...
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