Article
cn.FARMS: a latent variable model to detect copy number variations in microarray data with a low false discovery rate.
Nucleic acids research - 1 Jul 2011
Clevert Djork-Arné, Mitterecker Andreas, Mayr Andreas, Klambauer Günter, Tuefferd Marianne, De Bondt An, Talloen Willem, Göhlmann Hinrich, Hochreiter Sepp
Abstract excerpt
Cost-effective oligonucleotide genotyping arrays like the Affymetrix SNP 6.0 are still the predominant technique to measure DNA copy number variations (CNVs). However, CNV detection methods for microarrays overestimate both the number and the size of CNV regions and, consequently, suffer from a high false discovery rate (FDR). A high FDR means that many CNVs are wrongly detected and therefore not associated with...
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