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Article

Human papillomavirus vaccine: Widening the scope for cancer prevention

1 Apr 2011

Abstract excerpt

Human papillomavirus (HPV) is the necessary cause of cervical cancer. The HPV oncoproteins E6 and E7 have crucial roles in various steps of carcinogenesis, inducing degradation of p53 and destabilization of pRb. Several clinical trials show that recombinant HPV vaccines are safe and effective in preventing persistent infection of HPV and associated anogenital lesions. Although most clinical studies to date have...

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PMID: 21465574
DOI: 10.1002/mc.20657

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