Article
A Novel Method of Characterizing Genetic Sequences: Genome Space with Biological Distance and Applications
2 Mar 2011
Abstract excerpt
BACKGROUND: Most existing methods for phylogenetic analysis involve developing an evolutionary model and then using some type of computational algorithm to perform multiple sequence alignment. There are two problems with this approach: (1) different evolutionary models can lead to different results, and (2) the computation time required for multiple alignments makes it impossible to analyse the phylogeny of a...
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