A dynamic complex of signaling proteins uses polar localization to regulate cell-fate asymmetry in Caulobacter crescentus.

doi:10.1016/j.devcel.2011.01.007

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Article

A dynamic complex of signaling proteins uses polar localization to regulate cell-fate asymmetry in Caulobacter crescentus.

Developmental cell - 15 Mar 2011

Tsokos Christos G, Perchuk Barrett S, Laub Michael T

Abstract excerpt

Cellular asymmetry is critical to metazoan development and the life cycle of many microbes. In Caulobacter, cell cycle progression and the formation of asymmetric daughter cells depend on the polarly-localized histidine kinase CckA. How CckA is regulated and why activity depends on localization are unknown. Here, we demonstrate that the unorthodox kinase DivL promotes CckA activity and that the phosphorylated...

Topics

Bacterial Proteins
Caulobacter crescentus
Cell Cycle
Cell Polarity
Enzyme Activation
Epistasis, Genetic
Histidine Kinase
Mutation
Protein Kinases
Recombinant Fusion Proteins
Signal Transduction

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Identifiers

PMID: 21397844
DOI: 10.1016/j.devcel.2011.01.007
PMCID: PMC3068846

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