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Cord blood CD133 cells define an OV6-positive population that can be differentiated in vitro into engraftable bipotent hepatic progenitors.

Stem cells and development - 1 Nov 2011

Crema Annalisa, Ledda Mario, De Carlo Flavia, Fioretti Daniela, Rinaldi Monica, Marchese Rodolfo, Sanchez Massimo, Giuliani Massimo, Arena Vincenzo, Durrbach Antoine, Brunetti Ercole, Haas Cristina, Ponzetto Antonio, Lisi Antonella, Carloni Guido

Abstract excerpt

Cell therapy represents the most promising alternative strategy for end-stage liver diseases and hepatic progenitors are the best candidates. We have identified a reservoir of immature hepatic precursors within human cord blood, which can derive engraftable bipotent progenitors. We isolated a stem cell subset CD133+/CD34+/OV6(low) expressing a surface-marker profile consistent with that of fetal liver cells. Upon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21291316
DOI: 10.1089/scd.2010.0545

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