Article
Thermolabile CPT II variants and low blood ATP levels are closely related to severity of acute encephalopathy in Japanese children.
Brain & development - 1 Jan 2012
Kubota Masaya, Chida Junji, Hoshino Hideki, Ozawa Hiroshi, Koide Ayaka, Kashii Hirohumi, Koyama Akiko, Mizuno Yoko, Hoshino Ai, Yamaguchi Miyoko, Yao Dengbing, Yao Min, Kido Hiroshi
Abstract excerpt
Despite the decrease in Reye syndrome after the discontinuation of aspirin, acute encephalopathy (non-Reye syndrome type) has been continually reported in Japan. Recent studies suggested that the thermolabile phenotype of carnitine palmitoyltransferase II (CPT II) variation [F352C] was closely related to the pathomechanism of influenza-associated encephalopathy (IAE) in Japanese, causing mitochondrial ATP...
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