Historical Perspective: Beginnings of the β-Cell

Abstract excerpt

Over the course of the last half-century, we have gleaned much about the developmental biology of the pancreas and in particular the insulin-producing β-cell, the autoimmune destruction of which results in type 1 diabetes. Deciphering the mechanisms driving β-cell neogenesis in vivo holds great allure, in large part because of the potential therapeutic applications that stand to be gained. The field of pancreas...

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