Article
The power of NGS technologies to delineate the genome organization in cancer: from mutations to structural variations and epigenetic alterations.
Cancer metastasis reviews - 1 Jun 2011
Schweiger Michal R, Kerick Martin, Timmermann Bernd, Isau Melanie
Abstract excerpt
The development of cancer is characterized by the joined occurrence of alterations on different levels--from single nucleotide changes via structural and copy number variations to epigenetic alterations. With the advent of advanced technologies such as next generation sequencing, we have now the tools in hands to put some light on complex processes and recognize systematic patterns that develop throughout cancer...
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