Article
[Epigenetic mechanisms in major depression].
Der Nervenarzt - 1 Nov 2011
Paslakis G, Bleich S, Frieling H, Deuschle M
Abstract excerpt
The term epigenetics describes mechanisms that can change the function of genes in the absence of an alteration of the actual DNA sequence. Among others, histone protein modifications (methylation, acetylation and phosphorylation) and DNA methylation constitute epigenetic mechanisms. Histone methylation and histone deacetylation in promoter regions of neurotrophic factors that have been associated with depression...
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