Article
[The epigenetic mechanism of the effect of mildly deleterious mutations on the viability of the progeny and their correction in meiosis].
Genetika - 1 Oct 2010
Chubykin V L
Abstract excerpt
Data supporting the hypothesis about the epigenetic nature of deleterious mutations leading to the death of a part of the progeny are presented. It is assumed that during the life cycle "mutant" variants of formation of structural-functional loop domains occur in chromosomes that normally are corrected during meiosis. An abnormal loop changes the activity of many tens of genes, both increasing (+) and decresing...
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