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Targeted Next-Generation Sequencing for the Molecular Genetic Diagnostics of Cardiomyopathies

20 Jan 2011

Abstract excerpt

BACKGROUND: Today, mutations in more than 30 different genes have been found to cause inherited cardiomyopathies, some associated with very poor prognosis. However, because of the genetic heterogeneity and limitations in throughput and scalability of current diagnostic tools up until now, it is hardly possible to genetically characterize patients with cardiomyopathy in a fast, comprehensive, and cost-efficient...

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PMID: 21252143
DOI: 10.1161/circgenetics.110.958322

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