Article
Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenstrom macroglobulinemia.
Blood - 10 Mar 2011
Grass Sandra, Preuss Klaus-Dieter, Wikowicz Alexandra, Terpos Evangelos, Ziepert Marita, Nikolaus Diana, Yang Yin, Fadle Natalie, Regitz Evi, Dimopoulos Meletios A, Treon Steven P, Hunter Zachary R, Pfreundschuh Michael
Abstract excerpt
We recently described paratarg-7 (P-7), a protein of unknown function, as the target of 15% of immunoglobulin A (IgA) and IgG paraproteins in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma. To determine the frequency of P-7 as a paraprotein target in IgM-MGUS and Waldenström macroglobulinemia (WM), sera from patients with IgM-MGUS/WM were tested for reactivity with recombinant P-7...
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