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Article

Acceleration of Enterococcus faecalis biofilm formation by aggregation substance expression in an ex vivo model of cardiac valve colonization.

PloS one - 30 Dec 2010

Chuang-Smith Olivia N, Wells Carol L, Henry-Stanley Michelle J, Dunny Gary M

Abstract excerpt

Infectious endocarditis involves formation of a microbial biofilm in vivo. Enterococcus faecalis Aggregation Substance (Asc10) protein enhances the severity of experimental endocarditis, where it has been implicated in formation of large vegetations and in microbial persistence during infection. In the current study, we developed an ex vivo porcine heart valve adherence model to study the initial interactions...

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Identifiers

PMID: 21209892
DOI: 10.1371/journal.pone.0015798
PMCID: PMC3012704

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Source receipt: pubmed, retrieved 7 Sept 2026.

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