Article
A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG).
Molecular immunology - 1 Aug 1990
Mihaesco C, Ferrara P, Guillemot J C, Congy N, Gendron M C, Roy J P, Sizaret P Y, Mihaesco E
Abstract excerpt
The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain starts with an "extra sequence". The amino acid sequence of this segment is...
Topics
- Amino Acid Sequence
- Heavy Chain Disease
- Humans
- Immunoglobulin Fragments
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Molecular Sequence Data
- Molecular Weight
- Mutation