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Article

Characterization of sarcoplasmic reticulum Ca2+ ATPase nucleotide binding domain mutants using NMR spectroscopy.

Biochemical and biophysical research communications - 4 Feb 2011

Myint Wazo, Gong Qingguo, Ahn Jinwoo, Ishima Rieko

Abstract excerpt

Sarcoplasmic reticulum Ca(2+) ATPase (SERCA) is essential for muscle function by transporting Ca(2+) from the cytosol into the sarcoplasmic reticulum through ATP hydrolysis. In this report, the effects of substitution mutations on the isolated SERCA-nucleotide binding domain (SERCA-N) were studied using NMR. (15)N-(1)H HSQC spectra of substitution mutants at the nucleotide binding site, T441A, R560V, and C561A,...

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PMID: 21187073
DOI: 10.1016/j.bbrc.2010.12.094

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PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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