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Replication-competent Lentivirus Analysis of Clinical Grade Vector Products

21 Dec 2010

Abstract excerpt

Lentiviral vectors are now in clinical trials for a variety of inherited and acquired disorders. A challenge for moving any viral vector into the clinic is the ability to screen the vector product for the presence of replication-competent virus. Assay development for replication-competent lentivirus (RCL) is particularly challenging because recombination of vector packaging plasmids and cellular DNA leading to...

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PMID: 21179010
DOI: 10.1038/mt.2010.278

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