Article
Miliary never-smoking adenocarcinoma of the lung: strong association with epidermal growth factor receptor exon 19 deletion.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2011
Laack Eckart, Simon Ronald, Regier Marc, Andritzky Birte, Tennstedt Pierre, Habermann Christian, Verth Christoph Zur, Thöm Ina, Grob Tobias, Sauter Guido, Bokemeyer Carsten
Abstract excerpt
Miliary pattern of pulmonary metastases is a rarity in patients with lung cancer. We report five cases of patients with a never-smoking adenocarcinoma of the lung with such a pattern of metastases. In the tumor cells of all five patients, epidermal growth factor receptor (EGFR) mutation gene sequencing identified a deletion in exon 19 of the EGFR gene, and all five patients had a dramatic response to EGFR...
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