Article
Optimal management of patients with non-small cell lung cancer and epidermal growth factor receptor mutations.
Drugs - 1 Jan 2011
Lin Chia-Chi, Yang James Chih-Hsin
Abstract excerpt
In recent years, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), gefitinib and erlotinib, which have promising activity and a favourable toxicity profile, have been used in the management of advanced non-small cell lung cancer (NSCLC). The knowledge that EGFR-activating mutations confer sensitivity to EGFR TKIs has led to the design and analysis of phase II and III studies of...
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