Article
Ghrelin gene polymorphisms in rheumatoid arthritis.
Joint bone spine - 1 Jul 2011
Ozgen Metin, Koca Suleyman Serdar, Etem Ebru Onalan, Yuce Huseyin, Aydin Suleyman, Isik Ahmet
Abstract excerpt
OBJECTIVES: Ghrelin, an endogenous orexigenic peptide, has anti-inflammatory effects, down-regulates pro-inflammatory cytokines, and its altered levels are reported in various inflammatory diseases. The human preproghrelin (ghrelin/obestatin) gene shows several single nucleotide polymorphisms (SNPs) including Arg51Gln, Leu72Met, Gln90Leu, and A-501C. The aim of this study was to investigate the frequency, and...
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