Article
Personalized treatment in the eradication therapy for Helicobacter pylori.
International journal of molecular medicine - 1 Feb 2011
Jinda Sayaka, Nakatani Kaname, Nishioka Junji, Yasuda Kazunari, Soya Yoshihiro, Hayashi Amiko, Wada Hideo, Nobori Tsutomu
Abstract excerpt
Helicobacter pylori (HP) is known to be a causative bacterium of gastritis and peptic ulcers. The combination treatment consisting of a proton pump inhibitor (PPI), amoxicillin and clarithromycin (CAM) is widely used in eradication therapy, but the eradication fails in some patients. The main causes are CAM resistance of HP and individual variability in PPI metabolism related to the activity of the cytochrome...
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