Article
The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates.
PLoS pathogens - 24 Nov 2010
Kennan Ruth M, Wong Wilson, Dhungyel Om P, Han Xiaoyan, Wong David, Parker Dane, Rosado Carlos J, Law Ruby H P, McGowan Sheena, Reeve Shane B, Levina Vita, Powers Glenn A, Pike Robert N, Bottomley Stephen P, Smith A Ian, Marsh Ian, Whittington Richard J, Whisstock James C, Porter Corrine J, Rood Julian I
Abstract excerpt
Many bacterial pathogens produce extracellular proteases that degrade the extracellular matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter nodosus is the causative agent of ovine footrot, a highly contagious disease that is characterized by the separation of the hoof from the underlying tissue. D. nodosus secretes three subtilisin-like proteases whose analysis forms the basis of...
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