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Article

Correlation of camptothecin-producing ability and phylogenetic relationship in the genus Ophiorrhiza.

Planta medica - 1 May 2011

Viraporn Varalee, Yamazaki Mami, Saito Kazuki, Denduangboripant Jessada, Chayamarit Kongkanda, Chuanasa Taksina, Sukrong Suchada

Abstract excerpt

Camptothecin (CPT) is an essential precursor of semisynthetic chemotherapeutic agents for cancers throughout the world. In spite of the rapid growth of market demand, CPT raw material is still harvested by extraction from Camptotheca acuminata and Nothapodytes foetida because its total synthesis is not cost-effective. In this study, we examined eight species of the genus Ophiorrhiza (Rubiaceae) from Thailand as...

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PMID: 21104605
DOI: 10.1055/s-0030-1250568

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