Article
Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia.
Leukemia - 1 Jan 2011
Bixby D, Talpaz M
Abstract excerpt
Although only 5000 new cases of chronic myeloid leukemia (CML) were seen in the United States in 2009, this neoplasm continues to make scientific headlines year-after-year. Advances in understanding the molecular pathogenesis coupled with exciting developments in both drug design and development, targeting the initiating tyrosine kinase, have kept CML in the scientific limelight for more than a decade. Indeed,...
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